If like me you are looking for something a bit different in FS than programming the GPS/FMC in a jetliner glass cockpit and watching "Otto" make the flight virtually from just after take-off to touchdown check this site out:
http://www.calclassic.com/
Loads of old propliners, oozing atmosphere and character. Just started a flight in the DC7 (well, taxiing), when you start the engines each one pushes out a sheet of flame and a most magnificent growl - the aviation equivalent of a Class 37! The very basic autopilot means far more of the trip will need to be hand-flown.
And as a bonus, the content is all freeware too.