While we debate the future of Railworks in the other thread, N3V have fired their salvo and opened up pre-orders for their next version of Trainz, aka T:ANE.
Follow the link from their front page: http://forums.auran.com/trainz/index.php
Including shipping to the UK, current price via Paypal in GBP works out at £31.18 for the standard boxed edition. If you are content with the Download version, take off around £8 for shipping. Although pre-ordering so early met some resistance from SWMBO (she threatened to unplug the computer!) ordering with Paypal or a credit card presumably provides protection against N3V going belly up between now and December.